The review focused on the biological activity of various sulfones on different therapeutic targets. The aim of this review is to summarize the biological significance of sulfones, giving a comprehensive scenario and offer prospective in the development of new sulfone derivatives as therapeutic agents.
Gupta 1Nagendra S.
Chauhan 4Neeraj Upmanyu 2Sushant K. Prodrug approach deals with chemical biotransformation or enzymatic conversion or involves inactive or less active bio-reversible derivatives of active drug molecules.
They have to pass through enzymatic or chemical biotransformation before eliciting their pharmacological action.
The two different pharmacophores combine to give synergistic activity or may help in targeting the active drug to its target. Prodrug super seeds the problems of prodrug designing, for example solubility enhancement, bioavailability enhancement, chemical stability improvement, presystemic metabolism, site specific delivery, toxicity masking, improving patient acceptance, or eradicating undesirable adverse effects.
As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has continued during recent years. This present review emphasizes the common help to revamp physiochemical, pharmaceutical and therapeutic effectiveness of drugs.
This gives the researcher a common platform where they can find prodrugs of commonly used NSAIDs to overcome the gastrointestinal toxicity irritation, ulcergenocity and bleeding.Multipotent natural agents to combat Alzheimer’s disease.
Functional spectrum and structural features With the accelerated aging of human society, Alzheimer’s disease (AD) is becoming one of the biggest threats to human health. In spite of the availability of a large number of anti-inflammatory and analgesic agents, fighting pain and inflammation remains a common problem.
The current review article discusses the need of novel therapeutic targets for risk-free anti-inflammatory and analgesic therapy and summarizes some new agents in various stages of drug discovery pipeline.
The combination of two pharmacophores into a single molecule is an effective and commonly anti-inflammatory , antimicrobial , anti-HIV , antiviral , according seems to be a promising ‘hybrid pharmacophore’ approach to new anticancer agents. Since 1,3,4-thiadiazole and thiazolidinone moieties are.
Hybrid pharmacophores as anti inflammatory agents. At the border between bio-inspired design and rational design, one can imagine preparation of hybrid molecules with a dual mode of action to create efficient new drugs in this account, hybrid molecules are defined as chemical entities with two or more structural domains having different biological functions and dual activity, indicating that a.
“Discovery and optimization of new anticancer agents based on dual inhibition of heat shock protein 90 and Cyclin dependent kinase-1 via ligand-based and structure-based modeling followed by in-silico screening, biological evaluation and chemical optimization”.
Prodrugs of NSAIDs: A Review Kamal Shah 1, *, The two different pharmacophores combine to give synergistic activity or may help in targeting the active drug to its target. Prodrug super seeds the problems of prodrug designing, for example solubility enhancement, bioavailability enhancement, chemical stability improvement, presystemic.